Application Notes

Posters

Press Releases

Past Events

Application Notes

• Improving Triolein Measurement Accuracy in Mass Spectrometry Assays
  This application note describes the use of the HENDRIX SM100 ultrasonic fluid processor to release Triolein from the cell membrane bilayer and the RapidFire® technology to accurately detect native molecules. The combination showed significant improvements in MS assays triolein measurement accuracy.
  
  

• High-Quality Acoustic Instruments Compound Screening Duet
  This application note summarizes the high-quality compound screening process roadmap combining the use of HENDRIX SM100 ultrasonic fluid processor and high-throughput acoustic dispensers. HENDRIX SM100 protocol settings for common acoustic-friendly compound storage plate types are also available in this note.
  
  

Posters

• “Dial a DNA Fragment” - new DNA shearing data shows excellent reproducibility over a wide range of fragment sizes
  The data presented in this poster shows that Microsonic Systems Inc. has developed a unique, new ultrasonic technology “Bulk Lateral Ultrasonic (BLU)™ energy” and created a core building block the Microprocessor for Life Sciences™, to commercialize this exciting new technology, making possible a multi-channel DNA shearing device that will shear multiple DNA samples simultaneously.
  
  
Compound solubilization

• Improve the integrity of your fragment library for fragment-based drug discovery
  The data presented in this poster shows that the HENDRIX SM100 ultrasonic fluid processor can be used to recover precipitated fragment samples back into solution, and increase the sample concentration and thereby improve the accuracy of the screening results.
  
  
• Ultrasonic mixing & solubilization data
  This study performed by AstraZeneca shows that the HENDRIX SM100 ultrasonic fluid processor improves compound solubility and assay reproducibility. The HENDRIX increases compound potency in lead profiling and the total number of active compounds identified. These advantages led to the conclusion of implementing the HENDRIX SM100 in Compound Management and HTS at AstraZeneca.
  
  
Assay Mixing

• Evaluating five microplate mixing techniques: diffusion, centrifugation, shaking , pipetting and ultrasonic mixing
  This study shows that HENDRIX SM100 is the most rapid and efficient technique to achieve a well mixed state in smaller assay volumes.
  
  
• Mixing effectiveness - a methodology and study of microplate mixing techniques including ultrasonic HENDRIX SM100
  This poster describes a new method for measuring mixing effectiveness within one assay well. The results conclusively show that the mixing achieved by Lateral Ultrasonic Thrust^TM is far more effective than either diffusion or mechanical mixing.
  
  
• Ultrasonic mixing & solubilization data
  This study performed by AstraZeneca shows that the HENDRIX SM100 ultrasonic fluid processor improves compound solubility and assay reproducibility. The HENDRIX increases compound potency in lead profiling and the total number of active compounds identified. These advantages led to the conclusion of implementing the HENDRIX SM100 in Compound Management and HTS at AstraZeneca.
  
  
Technology overview

• Novel acoustic-wave micromixer device for mixing, solubilization, and isothermal thawing of microplates
  This poster explains how the novel Fresnel Annular Sector Actuator (FASA) elements - designed using Micro Electro Mechanical Systems (MEMS) technology - generate strong Lateral Ultrasonic Thrust^TM (LUT^TM) waves in liquid and enable many applications for the HENDRIX SM100 ultrasonic fluid processor.
  
  

Press Releases



• April, 2011
  Second-generation HENDRIX product targets primary compound solubilization.
  
  
• August, 2010
  Microsonic Systems enters Asia-Pacific market by partnering with Bio Laboratories and Kiko Tech.
  
  
• July, 2010
  Microsonic Systems HENDRIX SM100 Ultrasonic Fluid Processor wins 2010 R&D 100 Award.
  
  
• April, 2010
  Secondary recovery significantly improves screening quality of fragment libraries.
  
  
• February, 2010
  Microsonic Systems HENDRIX SM100 now serving four applications - solubilization, thawing, mixing and suspension.
  
  

Past Events



• March 27 - 31, 2011 – SBS 17th Annual Conference,Orlando, Florida. Booth # 925
  Click here for details
  
  
• August 26, 2010 – Press release: Microsonic Systems enters Asia-Pacific market.
  Click here for details
  
  
• July 9, 2010 – Press release: HENDRIX SM100 wins this year’s R&D 100 Award for its technological significance.
  Click here for details
  
  
• January 29 - February, 2011 – Lab Automation 2011, Palm Springs Convention Center, Palm Springs, CA. Booth # 378
  Click here for details
  
  
• June 1, 2010 – GEN assay tutorials: HENDRIX SM100 re-solubilizes fragment precipitates and can increase yields.
  Click here for details
  
  
• May 10, 2010 – SelectScience SBS interview: SVP Bruce Jamieson presented HENDRIX SM100 for rapid compound solubilization.
  Click here to watch video
  
  
• April 11-15, 2010 – Society for Biomolecular Sciences: SBS 2010 16th Annual Conference & Exhibition Phoenix, AZ
  Click here for details
  
  
• January 23-27, 2010 – ALA LabAutomation 2010: Palm Springs Convention Center, Palm Springs, CA Come see us at Booth 167!
  Click here for details
  
  
• December 1, 2009 – LRIG Bay Area Chapter: Integrating New Automation Tools into the Laboratory Workflow.
  Click here for details